WORLD
Microbes learned to escape from antibiotics in "hibernation"
Baku, July 2 (AZERTAC). The Israeli scientists found out that bacteria escape from antibiotics, simply falling into "hibernation" — is more exact, arranging duration of the gipobioza under time of effect of medicine. Researchers told about the experiments to the Nature magazine. Recently doctors and scientists sound alarm concerning resistance of an increasing number of pathogenic bacteria to antibiotics. If not to stop this process, in the next decades the main weapon of modern medicine becomes useless. Staff of the Jewish university in Jerusalem reports one more unfavourable news: along with resistance (ability to survive in the presence of an antibiotic) bacteria have one more strategy — tolerance: they simply endure even high concentration of medicines, falling into "hibernation". Being able gipobioza (rest) microbes cease to grow, activity processes in them are as much as possible slowed down — and antibiotics can't get into them. Moreover, it appeared that bacteria are capable to change duration gipobioza that that coincided over time effects of medicine. It was succeeded to establish it to researchers by means of experiment. Scientists entered colonies of intestinal sticks (E. coli) a big dose of ampicillin which killed 99,9 percent of microbes. Having waited while the survived individuals will breed, to them entered a new lethal dose. After several such cycles researchers noticed that the survived microbes escaped thanks to gipobiozu. Already through ten cycles of a bacterium learned to change duration gipobioza, bringing it into accord with time of action of a dose of medicine (it lifted from three to eight o'clock). As a result level of survival of microbes rose a hundred times. Genome of new strains of E. coli three genes, responsible for terms gipobioza helped to reveal Sekvenirovaniye, however the concrete biological mechanism of saving "timer" for scientists remained isn't clear.