The Azerbaijan State News Agency

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Early detection of immune changes prevents painful shingles in astronauts and Earth-bound patients

Baku, March 7 (AZERTAC). The physiological, emotional and psychological stress associated with spaceflight can result in decreased immunity that reactivates the virus that causes shingles, a disease punctuated by painful skin lesions. NASA has developed a technology that can detect immune changes early enough to begin treatment before painful lesions appear in astronauts and people here on Earth. This early detection and treatment will reduce the duration of the disease and the incidence of long-term consequences.

Spaceflight alters some elements of the human immune system: innate immunity, an early line of defense against infectious agents, and specific components of cellular immunity are decreased in astronauts. Astronauts do not experience increased incidence or severity of infectious disease during short-duration spaceflight, but NASA scientists are concerned about how the immune system will function over the long stays in space that may be required for exploration missions.

Selecting one or more biomarkers or indicators of immunity in healthy individuals is difficult, but the herpes viruses have become valuable tools in early detection of changes in the immune system, based largely on the astronaut studies. Eight herpes viruses may reside in the human body, and virtually all of us are infected by one or more of these viruses. Herpes viruses cause diseases including common "fever blisters" (herpes simplex virus or HSV), infectious mononucleosis (Epstein-Barr virus or EBV) and chicken pox and shingles (varicella zoster virus or VZV). In immune-suppressed individuals, herpes viruses may cause several types of cancer, such as carcinoma, lymphoproliferative disease and others.

The herpes viruses are already present in astronauts, as they are in at least 95 percent of the general adult population worldwide. So measuring the appearance of herpes viruses in astronaut body fluids serves as a much-needed immune biomarker. It is widely believed that various stressors associated with spaceflight are responsible for the observed decreased immunity. Researchers at NASA’s Johnson Space Center found that four human herpes viruses reactivate and appear in body fluids in response to spaceflight. Due to the reduced cellular immunity, the viruses are allowed to emerge from their latent state into active infectious agents. The multiplying viruses are released into saliva, urine or blood and can be detected and quantified by a polymerase chain reaction or PCR assay for each specific virus. The PCR assay detects viral DNA and is very sensitive and highly specific, allowing the user to selectively replicate viral DNA sequences. The finding of VZV in saliva of astronauts was the first report of VZV being reactivated and shed in asymptomatic individuals. Subsequently, the VZV shed in astronaut saliva was found to be intact and infectious, posing a risk of disease in uninfected individuals.

PCR technology also was utilized to study VZV-induced shingles in patients from the general population. This early-detection technology was used to facilitate early diagnosis of shingles in a 21-year-old patient, resulting in early medical intervention. This quick action prevented the formation of skin lesions and reduced the duration of pain associated with acute disease.

 

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