Baku, March 5, AZERTAC

People often put a lot of thought into getting a tattoo. But there's one thing most people forget to think about—what impact the tattoo might have on their health in the long run. What happens to the ink once it's in your skin? Does it all stay in the skin where it's visible, or does it travel further into the body?

The Medical Xpress reports that research has shown that tattoo ink does not just remain where it is injected. Particles from the ink can migrate to the lymph nodes, where they accumulate.

Researchers from the Department of Public Health and the Department of Clinical Research at the University of Southern Denmark (SDU), together with the University of Helsinki, have investigated whether this could have health consequences. Using data from Danish twin pairs, they found that tattooed individuals are more frequently diagnosed with skin and lymphoma cancers compared to those without tattoos.

The research is published in the journal BMC Public Health.

The lymph nodes are a crucial part of the immune system, helping to fight infections and filter harmful substances from the body.

When tattoo ink penetrates the skin, some of it is absorbed into the lymph nodes. The researchers are particularly concerned that tattoo ink may trigger chronic inflammation in the lymph nodes, which over time could lead to abnormal cell growth and an increased risk of cancer.

"We can see that ink particles accumulate in the lymph nodes, and we suspect that the body perceives them as foreign substances," explains Henrik Frederiksen, consultant in hematology at Odense University Hospital and clinical professor at SDU.

"This may mean that the immune system is constantly trying to respond to the ink, and we do not yet know whether this persistent strain could weaken the function of the lymph nodes or have other health consequences."

Studying this link is challenging because cancer can take years to develop. This means that exposure in youth may not lead to illness until decades later, making it difficult to measure a direct effect.

The study is based on data from the Danish Twin Tattoo Cohort, where researchers have information from more than 5,900 Danish twins. By analyzing tattoo patterns alongside cancer diagnoses, they found a higher occurrence of both skin and lymphoma cancers in tattooed individuals.

"The unique aspect of our approach is that we can compare twin pairs where one has cancer, but they otherwise share many genetic and environmental factors," says Jacob von Bornemann Hjelmborg, professor of biostatistics at SDU.

"This provides us with a stronger method for investigating whether tattoos themselves may influence cancer risk."

The results show that the link between tattoos and cancer is most evident in those with large tattoos—defined as bigger than a palm.

For lymphoma, the rate is nearly three times higher for the group of individuals with large tattoos compared to those without tattoos. This rate (more specifically, "hazard rate") accounts for age, the timing of the tattoo, and how long the individuals have been followed in the study.

"This suggests that the bigger the tattoo and the longer it has been there, the more ink accumulates in the lymph nodes. The extent of the impact on the immune system should be further investigated so that we can better understand the mechanisms at play," says Signe Bedsted Clemmensen, assistant professor of biostatistics at SDU.

Another study from the Danish Twin Tattoo Cohort shows that tattoos are becoming increasingly common. Researchers estimate that four in ten women and three in ten men will have tattoos by the age of 25.

The link to lymphoma has also been observed in an independent Swedish study from 2024.

Previous research has suggested that certain pigments in tattoo ink may be more problematic than others.

"In our study, we do not see a clear link between cancer occurrence and specific ink colors, but this does not mean that color is irrelevant. We know from other studies that ink can contain potentially harmful substances, and for example, red ink more often causes allergic reactions. This is an area we would like to explore further," says Bedsted Clemmensen.

The researchers now plan to investigate how ink particles affect the function of lymph nodes at a molecular level and whether certain types of lymphoma are more linked to tattoos than others.

"We want to gain a better understanding of the biological mechanisms—what happens in the lymph nodes when they are exposed to ink particles over decades? This can help us assess whether there is a real health risk and what we might do to reduce it," concludes Bedsted Clemmensen.