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WORLD

Diabetic rats cured with their own stem cells

08.10.2011 [12:39]
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Baku, October 8 (AZERTAC). A cure for diabetes could be sitting in our brains. Neural stem cells, extracted from rats via the nose, have been turned into pancreatic cells that can manufacture insulin to treat diabetes.

Next, the team extracted neural stem cells from the tissue and exposed them to Wnt3a - a human protein that switches on insulin production - and to an antibody that blocks a natural inhibitor of insulin production.

After multiplying the stem cells for two weeks, they placed them on thin sheets of collagen which act as a removable scaffold. This allowed the team to lay the sheets incorporating the cells on top of the rats` pancreas without harming the organ itself.

Within a week, concentrations of insulin in the blood of both type 1 and type 2 rats that had received treatment matched those in non-diabetic rats. Elevated blood glucose concentrations also returned to normal.

The cells successfully tackled diabetes for 19 weeks until researchers halted the treatment by removing the sheets of cells, after which the rats` diabetes returned.

Crucially, the cells did not have to be genetically manipulated outside of the body.

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