Scientists confirm anti-aging drug appears to prolong life in animals
Baku, June 23, AZERTAC
For centuries, humans have searched for ways to extend life. Alchemists never found the philosopher's stone, but scientists have consistently shown that a longer life can be attained by eating less – at least in certain lab animals, according to ScienceAlert. But can we find a way to live longer while still enjoying our food?
Compounds that mimic the biological effects of dieting could be the answer, and the two most popular diet-mimicking drugs are rapamycin and metformin. In a new study, my colleagues and I found that rapamycin prolongs life almost as consistently as eating less, whereas metformin does not.
Eating less, or dietary restriction, has been the gold standard for achieving a longer life ever since a study nearly a century ago in which laboratory rats that ate less surprised scientists by outliving their well-fed lab mates.
But for many people, sticking to a permanent diet is hard and far from enjoyable. Also, if taken to extremes, it can even be bad for health.
That is why we wanted to know whether drugs that are dieting mimics could bring the same benefit of eating less without the unwanted side-effects.
Rapamycin was first discovered in bacteria living in Easter Island soil in the 1970s, and medical professionals now use it to prevent organ-transplant rejection, as it is a powerful immunosuppressant. It works by blocking a molecular switch that tells cells when nutrients are abundant.
Metformin, meanwhile, is a synthetic descendant of a compound found in French lilac (also known as goat's rue) and is widely prescribed to control blood sugar in type 2 diabetes. Both drugs are involved in the body's ability to sense nutrients and energy, so biologists like us hoped they might copy the mechanisms activated by eating less.
To find out, we pooled the results of many studies to see if there were any overall patterns. We carefully examined thousands of scientific papers to finally home in on 167 studies on eight vertebrate species, from fish to monkeys, that provided sufficient details on survival and how the study was done.
Then we compared three longevity strategies: eating less, taking rapamycin and taking metformin.
We found that eating less still came out on top as the most consistent way to prolong life in all animals but rapamycin was close behind.
Metformin, in contrast, showed no clear benefit. The life-extension effect of eating less was the same in both sexes, and it didn't matter whether the diet plan involved eating smaller portions or intermittent fasting.
That makes rapamycin one of the most exciting leads for new anti-ageing therapies. Ageing might not be considered a disease, but it is a risk factor behind many diseases from cancer to dementia.
If we slow that underlying process, the benefit will be extra years of quality life and lower healthcare bills as the world's population grows older.
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