Study links pollutants to increase in risk of birth defects
Baku, October 25 (AZERTAC). Pesticides and pollutants are related to an alarming 450 percent increase in the risk of spina bifida and anencephaly in rural China, according to scientists at The University of Texas at Austin and Peking University.
Two of the pesticides found in high concentrations in the placentas of affected newborns and stillborn fetuses were endosulfan and lindane. Endosulfan is only now being phased out in the United States for treatment of cotton, potatoes, tomatoes and apples. Lindane was only recently banned in the United States for treatment of barley, corn, oats, rye, sorghum and wheat seeds.
Strong associations were also found between spina bifida and anencephaly and high concentrations of polycyclic aromatic hydrocarbons (PAHs), which are byproducts of burning fossil fuels such as oil and coal. Spina bifida is a defect in which the backbone and spinal canal do not close before birth. Anencephaly is the absence of a large part of the brain and skull.
The study, which was published in the Proceedings of the National Academy of Sciences, is the result of a more than decadelong collaboration between Finnell and a team of researchers in Shanxi, a province in northern China.
Working with public health officials in four rural counties in Shanxi, researchers collected placentas from 80 newborn or stillborn fetuses that suffered from spina bifida or anencephaly. Once a fetus or a newborn with such defects was identified as a case, the placenta of a healthy newborn with no congenital malformations born in the same hospital was selected as a control.
Finnell and his colleagues screened these placentas for the presence of a class of substances known as persistent organic pollutants (POPs). Common POPs include agricultural pesticides, industrial solvents and the byproducts of burning fuels such as oil and coal.
They found strong associations between the birth defects and high levels of a number of compounds present in commonly used pesticides. They also found elevated placental concentrations of PAHs.
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